Aqueous phase preparation of ultrasmall MoSe sub(2) nanodots for efficient photothermal therapy of cancer cells

Photothermal therapy (PTT) is a promising cancer treatment with both high effectiveness and fewer side effects. However, an ideal PTT agent not only needs strong absorption of near-infrared (NIR) light and high photothermal conversion efficiency, but also needs good biocompatibility, stability, and...

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Published inNanoscale Vol. 8; no. 5; pp. 2720 - 2726
Main Authors Yuwen, Lihui, Zhou, Jiajia, Zhang, Yuqian, Zhang, Qi, Shan, Jingyang, Luo, Zhimin, Weng, Lixing, Teng, Zhaogang, Wang, Lianhui
Format Journal Article
LanguageEnglish
Published 01.01.2016
Subjects
Biotechnology
Cancer
Lasers
Liquids
Nanostructure
Photothermal conversion
Side effects
Therapy
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Summary:Photothermal therapy (PTT) is a promising cancer treatment with both high effectiveness and fewer side effects. However, an ideal PTT agent not only needs strong absorption of near-infrared (NIR) light and high photothermal conversion efficiency, but also needs good biocompatibility, stability, and small size, which makes the design and preparation of a novel PTT agent a great challenge. In this work, we developed an ultrasonication-assisted liquid exfoliation method for the direct preparation of ultrasmall (2-3 nm) MoSe sub(2) nanodots (NDs) in aqueous solution and demonstrated their superior properties as a PTT agent. The as-prepared MoSe sub(2) NDs have strong absorption of NIR light and high photothermal conversion efficiency of about 46.5%. In vitro cellular experiments demonstrate that MoSe sub(2) NDs have negligible cytotoxicity and can efficiently kill HeLa cells (human cervical cell line) under NIR laser (785 nm) irradiation.
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ISSN:2040-3364
2040-3372
DOI:10.1039/c5nr08166a