In vivo super(31)P-MRS assessment of muscle-pH, cytolsolic-[Mg super(2+)] and phosphorylation potential after supplementing hypokaliuric renal stone patients with potassium and magnesium salts

• Published in: Magnetic resonance imaging Vol. 22; no. 5; pp. 715 - 719
• Main Authors: Mairiang, E, Hanpanich, P, Sriboonlue, P
• Format: Journal Article
• Language: English
• Published: 01.06.2004
• ISSN: 0730-725X
• DOI: 10.1016/j.mri.2004.01.038

Renal stone patients in rural northeast Thailand have a low potassium and magnesium status and low urinary excretion of citrate. We measured the changes of urinary citrate excretion and assessed in vivo skeletal muscle metabolism for intracellular-pH, cytosolic-[Mg super(2+)] and phosphorylation potential (using the phosphorus magnetic resonance spectroscopy super(31)P-MRS) after oral supplementation to hypokaliuric renal stone patients with oral potassium and magnesium salts. The patients comprised four groups: Group 1 (n = 10) control, Group 2 (n = 3), Group 3 (n = 5) and Group 4 (n = 6) supplemented for a month with potassium citrate, potassium citrate plus amino acid chelated magnesium, and potassium-magnesium citrate, respectively. Though urinary citrate excretion was increased in all three supplemented groups, the increases in intracellular- pH, cytosolic-[Mg super(2+)] and phosphocreatine (PCr)/ beta -ATP were prominent only in Group 3. The increase in PCr/ beta -ATP was also observed in Group 4.