Performance of sigma up 11 not equal to -Pittsburgh Compound B PET Binding Potential Images in the Detection of Amyloid Deposits on Equivocal Static Images

• Published in: The Journal of nuclear medicine (1978) Vol. 56; no. 12; p. 1910
• Main Authors: Hosokawa, Chisa, Ishii, Kazunari, Kimura, Yuichi, Hyodo, Tomoko, Hosono, Makoto, Sakaguchi, Kenta, Usami, Kimio, Shimamoto, Kenji, Yamazoe, Yuzuru, Murakami, Takamichi
• Format: Journal Article
• Language: English
• Published: 01.12.2015
• ISSN: 0161-5505

The goal of this study was to clarify whether binding potential (BP) images using 11C-Pittsburgh compound B (11C-PiB) and dynamic PET can reliably detect cortical amyloid deposits for patients whose 11C-PiB PET static images are ambiguous and whether visual ratings are affected by white matter retention. Static and BP images were constructed for 85 consecutive patients with cognitive impairment after 11C-PiB dynamic PET. Cortical uptake was visually assessed as positive, negative, or equivocal for both types of images. Quantitatively, the standardized uptake value ratio (SUVR) from the static image, the nondisplaceable BP from the dynamic image for mean gray matter uptake, and the ratio of gray matter uptake to white matter retention were compared among 11C-PiB-positive, 11C-PiB-equivocal, and 11C-PiB-negative groups. Forty-three scans were visually assessed as 11C-PiB-positive in both the static and the BP images. Ten scans were 11C-PiB-equivocal in the static images. In 8 of them, the BP images were 11C-PiB-positive, whereas the other 2 were 11C-PiB-equivocal. Thirty-two scans were assessed as 11C-PiB-negative in the static images. In the BP images, 4 were 11C-PiB-positive and 2 were 11C-PiB-equivocal. The mean gray matter uptake of 11C-PiB in SUVR and nondisplaceable BP, respectively, showed statistically significant differences among the 11C-PiB-positive, 11C-PiB-equivocal, and 11C-PiB-negative groups. The ratio of gray matter uptake to white matter retention was lower in the BP images than static images from the 11C-PiB-negative and 11C-PiB-equivocal groups, whereas it was higher in the 11C-PiB-positive group. 11C-PiB PET BP images can clarify visual interpretation of clinical static 11C-PiB-equivocal images by reducing the interference of nonspecific white matter retention. We conclude that 11C-PiB-equivocal PET findings on static images reflect cortical amyloid deposits, which can be verified using BP images. Furthermore, quantitative assessments, such as SUVR and nondisplaceable BP, are of no use for correctly rating equivocal visual findings.