Molecular evidence for multiple UDP-glucuronosyltransferase gene families in fish

The presence of multiple distinct UGT genes in fish was derived by analysis of DNA sequence data derived the zebrafish EST project, confirming indications from previous protein purification studies in another fish species, the plaice, for a diversity of isoforms in lower vertebrates. At least 10 dif...

Full description

Saved in:
Bibliographic Details
Published inMarine environmental research Vol. 54; no. 2-5; pp. 253 - 257
Main Authors George, S G, Taylor, B
Format Journal Article
LanguageEnglish
Published 01.03.2002
Subjects
Danio rerio
Marine
Pleuronectes platessa
Online AccessGet full text

Cover

More Information
Summary:The presence of multiple distinct UGT genes in fish was derived by analysis of DNA sequence data derived the zebrafish EST project, confirming indications from previous protein purification studies in another fish species, the plaice, for a diversity of isoforms in lower vertebrates. At least 10 different UGTs can be identified from nucleotide sequence data in zebrafish. Phlyogenetic analysis of exon 1 sequences of the zebrafish, plaice and human UGTs indicates that six of these genes are related to the 1A, 1B and 2 families and that a further four genes were of more ancient lineage. Importantly data for the 3ui sequences of the zebrafish clones, both from the database and our own sequences of the publicly available clones did not provide any evidence for elaboration of family 1A genes by alternative splicing in this lower vertebrate.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
content type line 23
ObjectType-Conference-3
SourceType-Conference Papers & Proceedings-2
ObjectType-Feature-1
ISSN:0141-1136