Murine chromosome 16 telomeric region, homologous with human chromosome 21q22, contains the osmoregulatory Na super(+)/myo-inositol cotransporter (SLC5A3) gene

The murine Na super(+)/myo-inositol cotransporter (SLC5A3) gene (Slc5a3) was cloned, the restriction sites mapped, and the coding region sequenced. Similar to other mammalian counterparts, including human, the gene has a single coding exon, with an open reading frame of 2.2 kb. The predicted protein...

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Published inCytogenetics and cell genetics Vol. 88; no. 1-2; pp. 153 - 158
Main Authors McVeigh, KE, Mallee, JJ, Lucente, A, Barnoski, B L, Wu, S, Berry, G T
Format Journal Article
LanguageEnglish
Published 01.01.2000
Subjects
chromosome 16
chromosome 21
myo-inositol
SLC5A3 gene
sodium/myo-inositol cotransporter
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Summary:The murine Na super(+)/myo-inositol cotransporter (SLC5A3) gene (Slc5a3) was cloned, the restriction sites mapped, and the coding region sequenced. Similar to other mammalian counterparts, including human, the gene has a single coding exon, with an open reading frame of 2.2 kb. The predicted protein of 718 amino acids is also highly conserved, compared to other mammalian homologs. Using fluorescence in situ hybridization, Slc5a3 was localized to the telomeric region of mouse chromosome 16, which is syntenic to human chromosome 21q22. An increased Slc5a3 copy number may explain the increased levels of myo-inositol in the brains of trisomy 16 mice and the increased rate of transport of myo-inositol into cultured neurons derived from trisomy 16 mice.
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ISSN:0301-0171