HLA class I and class II genotyping in patients with chronic idiopathic urticaria

• Published in: Genes and immunity Vol. 6; p. S39
• Main Authors: Coban, M, Erdem, T, Ozdemir, S, Pirim, I, Atasoy, M
• Format: Journal Article
• Language: English
• Published: 01.04.2005
• ISSN: 1466-4879

Chronic idiopathic urticaria (CIU) is a common disease of which pathogenesis is unclear and resistant to therapy. Recent investigations have indicated that autoimmunity plays role in nearly one third of CIU patients. The present study aimed to investigate the relationship between HLA (Human leukocyte antigen) class I and class II antigens and immune pathogenesis of CIU. HLA class I and class II antigens were investigated in 40 patients diagnosed as CIU utilizing serologic technique and PCR (polymerase chain reactions). Further HLA typing on patients subsets, classified by the response of patients to intradermal injection of autologous serum. Thirty healthy and genetically unrelated individuals were evaluated as control group. The result show that the HLA-B44 frequency was significantly higher (25%) in patient group as compared with matched group (3.33%), (P=0.033 O.R=9.667). There was no significant difference in the HLA-A allelic distribution between the patient and control groups. In the genotyping of Class II HLA alleles, HLA-DRB1*01 (25%), (P=0.033 O.R=9.667) and HLA-DRB*15 (25%), (P=0.033 O.R=9.667) were predominant alleles in patients group.