Effects of polymorphisms in beta sub(1)-adrenoceptor and alpha -subunit of G protein on heart rate and blood pressure during exercise test. The Finnish Cardiovascular Study

• Published in: Journal of applied physiology (1985) Vol. 100; no. 2; pp. 507 - 511
• Main Authors: Nieminen, Tuomo, Lehtimaeki, Terho, Laiho, Jarno, Rontu, Riikka, Niemelae, Kari, Koeoebi, Tiit, Lehtinen, Rami, Viik, Jari, Turjanmaa, Vaeinoe, Kaehoenen, Mika
• Format: Journal Article
• Language: English
• Published: 01.02.2006
• ISSN: 8750-7587; 1522-1601

We tested whether the Arg389Gly and Ser49Gly polymorphisms of the beta sub(1)-adrenergic receptor gene ADRB1 and the T393C polymorphism of the G protein alpha -subunit gene GNAS1 modulate heart rate (HR) and blood pressure responses during an exercise stress test. The study population comprised 890 participants (563 men and 327 women, mean age 58.1 plus or minus 12.6 yr) of the Finnish Cardiovascular Study. Their HR, systolic (SAP), and diastolic arterial pressures (DAP) at rest, during exercise, and 4 min after the test were measured and analyzed by repeated-measurement ANOVA (RANOVA). Genotypes were detected by TaqMan 5' nuclease assay. In all subjects, and in men and women separately, the T393C of GNAS1 was the only polymorphism with genotype x time interaction in HR over the three study phases (P = 0.04, RANOVA). None of the polymorphisms presented genotype x time interaction in SAP or DAP responses (P > 0.10, RANOVA). In all subjects at rest, the Ser49Gly polymorphism of ADRB1 tended (P = 0.06, ANOVA) to differentiate HR. Arg389Gly polymorphism of ADRB1 affected maximal SAP during exercise (P = 0.04, ANOVA) and the change in SAP from rest to maximal (P = 0.03, ANOVA). Arg389 homozygotes, particularly men, were less likely to have ventricular extrasystoles during the exercise (odds ratio = 0.68, 95% confidence interval = 0.51-0.91, P = 0.009, and odds ratio = 0.60, 95% confidence interval = 0.42-0.86, P = 0.006, respectively) than did Gly389 carriers. In conclusion, polymorphisms examined appear to have modulatory effects on hemodynamics in a clinical exercise test setting. However, the effects in absolute numbers were minor and clinically possibly insignificant.