Pyridobenzodiazepines: A novel class of orally active, vasopressin V sub(2) receptor selective agonists

Our efforts in seeking low molecular weight agonists of the antidiuretic peptide hormone arginine vasopressin (AVP) have led to the identification of the clinical candidate WAY-151932 (VNA-932). Further exploration of the structural requirements for agonist activity has provided another class of pot...

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Published inBioorganic & medicinal chemistry letters Vol. 16; no. 4; pp. 954 - 959
Main Authors Failli, Amedeo A, Shumsky, Jay S, Steffan, Robert J, Caggiano, Thomas J, Williams, David K, Trybulski, Eugene J, Ning, Xiaoping, Lock, Yeungwai, Tanikella, Tarak, Hartmann, David, Chan, Peter S, Park, CH
Format Journal Article
LanguageEnglish
Published 01.02.2006
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Summary:Our efforts in seeking low molecular weight agonists of the antidiuretic peptide hormone arginine vasopressin (AVP) have led to the identification of the clinical candidate WAY-151932 (VNA-932). Further exploration of the structural requirements for agonist activity has provided another class of potent, orally active, non-peptidic vasopressin V sub(2) receptor selective agonists exemplified by the 5,11-dihydro-pyrido[2,3-b][1,5]benzodiazepine as a candidate for further development.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
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ObjectType-Feature-1
ISSN:0960-894X
1464-3405
DOI:10.1016/j.bmcl.2005.10.107