Continuous flow reactor for BalzaSchiemann reaction: a new procedure for the preparation of aromatic fluorides

A facile and highly efficient procedure for the preparation of aromatic fluorides by BalzaSchiemann reaction via two continuous flow reactors has been set up. The continuous diazotization reactor was run at about 25 degree C with residence times of 10a20 s, and the continuous fluorodediazoniation re...

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Published inTetrahedron letters Vol. 54; no. 10; pp. 1261 - 1263
Main Authors Yu, Zhi-qun, Lv, Yan-wen, Yu, Chuan-ming, Su, Wei-ke
Format Journal Article
LanguageEnglish
Published 06.03.2013
Subjects
Continuous flow
Fluorides
Heat transfer
Reaction time
Reactors
Tetrahedrons
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Summary:A facile and highly efficient procedure for the preparation of aromatic fluorides by BalzaSchiemann reaction via two continuous flow reactors has been set up. The continuous diazotization reactor was run at about 25 degree C with residence times of 10a20 s, and the continuous fluorodediazoniation reactor was performed with a residence time of 1 min in high yields. The reaction times can be greatly reduced by increasing temperature and thereby taking advantage of superior mass and heat transfer of a continuous flow system.
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ISSN:0040-4039