Continuous flow reactor for BalzaSchiemann reaction: a new procedure for the preparation of aromatic fluorides
A facile and highly efficient procedure for the preparation of aromatic fluorides by BalzaSchiemann reaction via two continuous flow reactors has been set up. The continuous diazotization reactor was run at about 25 degree C with residence times of 10a20 s, and the continuous fluorodediazoniation re...
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Published in | Tetrahedron letters Vol. 54; no. 10; pp. 1261 - 1263 |
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Main Authors | , , , |
Format | Journal Article |
Language | English |
Published |
06.03.2013
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Subjects | |
Online Access | Get full text |
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Summary: | A facile and highly efficient procedure for the preparation of aromatic fluorides by BalzaSchiemann reaction via two continuous flow reactors has been set up. The continuous diazotization reactor was run at about 25 degree C with residence times of 10a20 s, and the continuous fluorodediazoniation reactor was performed with a residence time of 1 min in high yields. The reaction times can be greatly reduced by increasing temperature and thereby taking advantage of superior mass and heat transfer of a continuous flow system. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 content type line 23 ObjectType-Feature-2 |
ISSN: | 0040-4039 |