A novel method for the synthesis of 3,4-disubstitutedpyrrole-2,5-dicarboxylates from hydrazones derived from I--diazo esters

Hydrazones obtained from I--diazo esters were converted to pyrroles when heated with thionyl chloride in alcohol. Among hydrazones, those substituted with a benzene ring on the I2-carbon to the ester are likely to give pyrroles in good yields.

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Bibliographic Details
Published inTetrahedron Vol. 69; no. 21; pp. 4325 - 4330
Main Authors Yasui, Eiko, Wada, Masao, Nagumo, Shinji, Takamura, Norio
Format Journal Article
LanguageEnglish
Published 01.05.2013
Subjects
Alcohols
Benzene
Chlorides
Esters
Hydrazones
Pyrroles
Synthesis
Tetrahedrons
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Summary:Hydrazones obtained from I--diazo esters were converted to pyrroles when heated with thionyl chloride in alcohol. Among hydrazones, those substituted with a benzene ring on the I2-carbon to the ester are likely to give pyrroles in good yields.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:0040-4020
DOI:10.1016/j.tet.2013.03.037