Preparation of novel multifunctional amino alcohols from nitroparaffins and I-,I2-unsaturated aldehydes

A series of novel multifunctional amino alcohols were prepared by tandem MichaelaHenry reaction by reacting nitroalkanes such as 2-nitropropane with readily available I-,I2-unsaturated aldehydes. The dinitro compounds were further reduced by catalytic hydrogenation to obtain respective diamines. Thi...

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Bibliographic Details
Published inTetrahedron letters Vol. 53; no. 26; pp. 3322 - 3324
Main Authors Peera, Asghar A, Tomlinson, Ian A
Format Journal Article
LanguageEnglish
Published 27.06.2012
Subjects
Alcohols
Aldehydes
Catalysis
Catalysts
Diamines
Hydrogenation
Tetrahedrons
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Summary:A series of novel multifunctional amino alcohols were prepared by tandem MichaelaHenry reaction by reacting nitroalkanes such as 2-nitropropane with readily available I-,I2-unsaturated aldehydes. The dinitro compounds were further reduced by catalytic hydrogenation to obtain respective diamines. This synthetic route provides a very convenient method of preparing multifunctional amino alcohols.
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ISSN:0040-4039
DOI:10.1016/j.tetlet.2012.04.078