Trypanosoma-Cruzi Cross-Reactive Antibodies Longitudinal Follow-Up: A Prospective Observational Study in Hematopoietic Stem Cell Transplantation: e0137240

• Published in: PloS one Vol. 10; no. 9
• Main Authors: Saba, Esber S, Gueyffier, Lucie, Danjoy, Marie-Laure, Vanhems, Philippe, Pozzetto, Bruno, Sobh, Mohamad, Pottel, Hans, Michallet, Mauricette, Zrein, Maan A
• Format: Journal Article
• Language: English
• Published: 01.09.2015
• Subjects: Trypanosoma cruzi
• ISSN: 1932-6203
• DOI: 10.1371/journal.pone.0137240

Antibodies named TcCRA "Trypanosoma cruzi Cross Reactive Antibodies" were detected in 47% of blood donors from French population unexposed to the parasite. In order to evaluate the passive or active transmissibility of TcCRA and further characterize its role and etiology, we have conducted a study in a cohort of 47 patients who underwent allogeneic Hematopoietic Stem Cell Transplantations (allo-HSCT). Donors and recipients were tested for TcCRA prior to transplantation. Recipients were further tested during follow-up after transplantation. Demographical, clinical and biological data were collected. Our primary end-point was to assess the risk of TcCRA acquisition after transplantation. During this initial analysis, we observed no seroconversion in patients receiving cells from TcCRA negative donors (n = 23) but detected seroconversion in 4 out of 24 patients who received hematopoietic stem cells from positive donors. Here, we are discussing possible scenarios to explain TcCRA-immune status in recipient after transplantation.