5-Piperazinyl pyridine carboxamide bradykinin B sub(1) antagonists

A series of 2,3-diaminopyridine bradykinin B sub(1) antagonists was modified to mitigate the potential for bioactivation. Removal of the 3-amino group and incorporation of basic 5-piperazinyl carboxamides at the pyridine 5-position provided compounds with high affinity for the human B sub(1) recepto...

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Published inBioorganic & medicinal chemistry letters Vol. 16; no. 10; pp. 2791 - 2795
Main Authors Kuduk, Scott D, Di Marco, Christina Ng, Chang, Ronald K, Wood, Michael R, Kim, June J, Schirripa, Kathy M, Murphy, Kathy L, Ransom, Richard W, Tang, Cuyue, Torrent, Maricel, Ha, Sookhee, Prueksaritanont, Thomayant, Pettibone, Douglas J, Bock, Mark G
Format Journal Article
LanguageEnglish
Published 01.01.2006
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Summary:A series of 2,3-diaminopyridine bradykinin B sub(1) antagonists was modified to mitigate the potential for bioactivation. Removal of the 3-amino group and incorporation of basic 5-piperazinyl carboxamides at the pyridine 5-position provided compounds with high affinity for the human B sub(1) receptor.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:0960-894X
1464-3405
DOI:10.1016/j.bmcl.2006.01.112