Selective changes in single cell GABA sub(A) receptor subunit expression and function in temporal lobe epilepsy

Temporal lobe epilepsy is the most prevalent seizure disorder in adults. Compromised inhibitory neurotransmitter function in the hippocampus contributes to the hyperexcitability generating this condition, but the underlying molecular mechanisms are unknown. Combining patch-clamp recording and single...

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Published inNature medicine Vol. 4; no. 10; pp. 1166 - 1172
Main Authors Brooks-Kayal, A R, Shumate, MD, Jin, H, Rikhter, TY, Coulter, DA
Format Journal Article
LanguageEnglish
Published 01.10.1998
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Summary:Temporal lobe epilepsy is the most prevalent seizure disorder in adults. Compromised inhibitory neurotransmitter function in the hippocampus contributes to the hyperexcitability generating this condition, but the underlying molecular mechanisms are unknown. Combining patch-clamp recording and single-cell mRNA amplification (aRNA) techniques in single dentate granule cells, we demonstrate that expression of GABA sub(A) receptor subunit mRNAs is substantially altered in neurons from epileptic rats. These changes in gene expression precede epilepsy onset by weeks and correlate with profound alterations in receptor function, indicating that aberrant GABA sub(A) receptor expression and function has an essential role in the process of epileptogenesis.
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ISSN:1078-8956