Synthesis of Aromatic [alpha]-Aminoesters: Palladium-Catalyzed Long-Range Arylation of Primary C[Formulaomitted]--H Bonds

• Published in: Angewandte Chemie International Edition Vol. 51; no. 43; pp. 10808 - 10811
• Main Authors: Aspin, Sam, Goutierre, Anne-Sophie, Larini, Paolo, Jazzar, Rodolphe, Baudoin, Olivier
• Format: Journal Article
• Language: English
• Published: 01.10.2012
• Subjects: Aromatic compounds; Bromides; Esters; Homology; Remote control; Synthesis; Terminals

Remote control: The title reaction for [beta]-[zeta]arylation of [alpha]-amino esters with aryl bromides is described. This reaction, which occurs selectively at the terminal position of linear alkyl chains, gives rise to synthetically useful (hetero)arylalanines and homologues after debenzylation (...