Synthesis of Aromatic [alpha]-Aminoesters: Palladium-Catalyzed Long-Range Arylation of Primary C[Formulaomitted]--H Bonds

Remote control: The title reaction for [beta]-[zeta]arylation of [alpha]-amino esters with aryl bromides is described. This reaction, which occurs selectively at the terminal position of linear alkyl chains, gives rise to synthetically useful (hetero)arylalanines and homologues after debenzylation (...

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Published inAngewandte Chemie International Edition Vol. 51; no. 43; pp. 10808 - 10811
Main Authors Aspin, Sam, Goutierre, Anne-Sophie, Larini, Paolo, Jazzar, Rodolphe, Baudoin, Olivier
Format Journal Article
LanguageEnglish
Published 01.10.2012
Subjects
Aromatic compounds
Bromides
Esters
Homology
Remote control
Synthesis
Terminals
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Summary:Remote control: The title reaction for [beta]-[zeta]arylation of [alpha]-amino esters with aryl bromides is described. This reaction, which occurs selectively at the terminal position of linear alkyl chains, gives rise to synthetically useful (hetero)arylalanines and homologues after debenzylation (see scheme).
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ObjectType-Feature-2
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.201206237