Anti-IL-10 antibody enhances the proliferation of CD8 super(+) T cell clones: Autoregulatory role of murine IL-10 in CD8 super(+) T cells
All CD8 super(+) T cell clones used in this study secreted IL-10, and their proliferation was inhibited by exogenous IL-10. This study addresses the question of whether IL-10 produced by responding T cell clones would inhibit proliferation of the secreting T cells themselves. Anti-IL-10 antibodies e...
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| Published in | Cellular immunology Vol. 154; no. 1; pp. 193 - 201 |
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| Main Authors | , , , , |
| Format | Journal Article |
| Language | English |
| Published |
01.01.1994
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| Online Access | Get full text |
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| Abstract | All CD8 super(+) T cell clones used in this study secreted IL-10, and their proliferation was inhibited by exogenous IL-10. This study addresses the question of whether IL-10 produced by responding T cell clones would inhibit proliferation of the secreting T cells themselves. Anti-IL-10 antibodies enhanced the proliferative response of the CD8 super(+) T cell clones, the enhancing effect appearing in the late period of proliferation. This is the first report on a lymphokine which has an autoregulatory role in inhibiting T cell proliferation. |
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| AbstractList | All CD8 super(+) T cell clones used in this study secreted IL-10, and their proliferation was inhibited by exogenous IL-10. This study addresses the question of whether IL-10 produced by responding T cell clones would inhibit proliferation of the secreting T cells themselves. Anti-IL-10 antibodies enhanced the proliferative response of the CD8 super(+) T cell clones, the enhancing effect appearing in the late period of proliferation. This is the first report on a lymphokine which has an autoregulatory role in inhibiting T cell proliferation. |
| Author | Kaminogawa, S Kohyama, M Nishijima, K Hisatsune, T Minai, Y |
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| Snippet | All CD8 super(+) T cell clones used in this study secreted IL-10, and their proliferation was inhibited by exogenous IL-10. This study addresses the question... |
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| Title | Anti-IL-10 antibody enhances the proliferation of CD8 super(+) T cell clones: Autoregulatory role of murine IL-10 in CD8 super(+) T cells |
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