Anti-IL-10 antibody enhances the proliferation of CD8 super(+) T cell clones: Autoregulatory role of murine IL-10 in CD8 super(+) T cells

All CD8 super(+) T cell clones used in this study secreted IL-10, and their proliferation was inhibited by exogenous IL-10. This study addresses the question of whether IL-10 produced by responding T cell clones would inhibit proliferation of the secreting T cells themselves. Anti-IL-10 antibodies e...

Full description

Saved in:
Bibliographic Details
Published inCellular immunology Vol. 154; no. 1; pp. 193 - 201
Main Authors Nishijima, K, Hisatsune, T, Minai, Y, Kohyama, M, Kaminogawa, S
Format Journal Article
LanguageEnglish
Published 01.01.1994
Online AccessGet full text

Cover

More Information
Summary:All CD8 super(+) T cell clones used in this study secreted IL-10, and their proliferation was inhibited by exogenous IL-10. This study addresses the question of whether IL-10 produced by responding T cell clones would inhibit proliferation of the secreting T cells themselves. Anti-IL-10 antibodies enhanced the proliferative response of the CD8 super(+) T cell clones, the enhancing effect appearing in the late period of proliferation. This is the first report on a lymphokine which has an autoregulatory role in inhibiting T cell proliferation.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
content type line 23
ObjectType-Feature-1
ISSN:0008-8749