Comparative Study of Polycomplexes Based on Carbopol super( registered ) and Oppositely Charged Polyelectrolytes as a New Oral Drug Delivery System
We report here a comparative study of the release of model drug diclofenac sodium from samples of interpolyelectrolyte complexes (IPEC) in in vitro conditions on a rotating basket apparatus and in vivo in experiments in rabbits. The study IPEC were prepared using different grades of Carbopol super(...
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| Published in | Pharmaceutical chemistry journal Vol. 49; no. 1; pp. 1 - 6 |
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| Main Authors | , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
01.04.2015
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| Online Access | Get full text |
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| Abstract | We report here a comparative study of the release of model drug diclofenac sodium from samples of interpolyelectrolyte complexes (IPEC) in in vitro conditions on a rotating basket apparatus and in vivo in experiments in rabbits. The study IPEC were prepared using different grades of Carbopol super( registered ) polymer (C71g, C2020) and Noveon super( registered ) AA-1 and oppositely charged polyelectrolytes - Eudragit super( registered ) EPO or the natural polysaccharide low-viscosity chitosan. These studies demonstrated the potential for IPEC samples based on Carbopol super( registered ) as a new modified-release drug delivery system. At the same time, assessment of bioadhesive properties provided evidence of the potential for using IPEC based on C2020/EPO as a mucoadhesive carrier. |
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| AbstractList | We report here a comparative study of the release of model drug diclofenac sodium from samples of interpolyelectrolyte complexes (IPEC) in in vitro conditions on a rotating basket apparatus and in vivo in experiments in rabbits. The study IPEC were prepared using different grades of Carbopol super( registered ) polymer (C71g, C2020) and Noveon super( registered ) AA-1 and oppositely charged polyelectrolytes - Eudragit super( registered ) EPO or the natural polysaccharide low-viscosity chitosan. These studies demonstrated the potential for IPEC samples based on Carbopol super( registered ) as a new modified-release drug delivery system. At the same time, assessment of bioadhesive properties provided evidence of the potential for using IPEC based on C2020/EPO as a mucoadhesive carrier. |
| Author | Semina, I I Mustafin, R I Garipova, V R Bukhovets, A V Sitenkov, AYu Gennari, CGM Cilurzo, F Salakhova, A R |
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| Title | Comparative Study of Polycomplexes Based on Carbopol super( registered ) and Oppositely Charged Polyelectrolytes as a New Oral Drug Delivery System |
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