Comparative Study of Polycomplexes Based on Carbopol super( registered ) and Oppositely Charged Polyelectrolytes as a New Oral Drug Delivery System

We report here a comparative study of the release of model drug diclofenac sodium from samples of interpolyelectrolyte complexes (IPEC) in in vitro conditions on a rotating basket apparatus and in vivo in experiments in rabbits. The study IPEC were prepared using different grades of Carbopol super(...

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Published inPharmaceutical chemistry journal Vol. 49; no. 1; pp. 1 - 6
Main Authors Mustafin, R I, Semina, I I, Garipova, V R, Bukhovets, A V, Sitenkov, AYu, Salakhova, A R, Gennari, CGM, Cilurzo, F
Format Journal Article
LanguageEnglish
Published 01.04.2015
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Summary:We report here a comparative study of the release of model drug diclofenac sodium from samples of interpolyelectrolyte complexes (IPEC) in in vitro conditions on a rotating basket apparatus and in vivo in experiments in rabbits. The study IPEC were prepared using different grades of Carbopol super( registered ) polymer (C71g, C2020) and Noveon super( registered ) AA-1 and oppositely charged polyelectrolytes - Eudragit super( registered ) EPO or the natural polysaccharide low-viscosity chitosan. These studies demonstrated the potential for IPEC samples based on Carbopol super( registered ) as a new modified-release drug delivery system. At the same time, assessment of bioadhesive properties provided evidence of the potential for using IPEC based on C2020/EPO as a mucoadhesive carrier.
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ISSN:0091-150X
1573-9031
DOI:10.1007/s11094-015-1211-2