Microencapsulation of Coenzyme Q sub(10) in Poly(ethylene glycol) and Poly(lactic acid) with Supercritical Carbon Dioxide

The rapid expansion of supercritical solutions (RESS) process was applied to produce polymeric microparticles loaded with coenzyme Q sub(10) (coQ sub(10)). Mixtures of poly(lactic acid) (PLA)/(coQ sub(10)) and poly(ethylene glycol) (PEG)/(coQ sub(10)) containing a cosolvent were dissolved in supercr...

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Bibliographic Details
Published inIndustrial & engineering chemistry research Vol. 51; no. 17; pp. 5840 - 5846-5840-5846
Main Authors Vergara-Mendoza, Maria del Socorro, Ortiz-Estrada, Ciro-Humberto, Gonzalez-Martinez, Juana, Quezada-Gallo, Jesus-Alberto
Format Journal Article
LanguageEnglish
Published 02.05.2012
Subjects
Carbon dioxide
Coenzymes
Differential scanning calorimetry
Dissolution
Electronics
Encapsulating
Glycols
Process parameters
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Summary:The rapid expansion of supercritical solutions (RESS) process was applied to produce polymeric microparticles loaded with coenzyme Q sub(10) (coQ sub(10)). Mixtures of poly(lactic acid) (PLA)/(coQ sub(10)) and poly(ethylene glycol) (PEG)/(coQ sub(10)) containing a cosolvent were dissolved in supercritical CO sub(2) and sprayed through a nozzle to atmospheric pressure. The effect of process parameters such as encapsulating material/coQ sub(10) ratio and cosolvent on the properties of the microcapsules were investigated. The characterization of microcapsules was carried out through Scanning Electronic Microscopy (SEM), Infrared Spectrophotometry (IR), Differential Scanning Calorimetry (DSC), and solubility kinetics. More important effect of the ratio encapsulating material/coQ sub(10), compared with the effect of type of cosolvent, on studied properties was found.
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ISSN:0888-5885
1520-5045
DOI:10.1021/ie2014839