Comparison of biological characteristics of EDTMP complexes with super(99m)Tc, super(111)In and super(153)Sm in rats

The pharmacokinetics and elimination of EDTMP chelates with different radionuclides ( super(99m)Tc, super(111)In and super(153)Sm) has been investigated in rats. The biodistribution of the complexes under study was similar and two main processes, namely bone uptake and the elimination of glomerular...

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Published inApplied radiation and isotopes Vol. 45; no. 9; pp. 949 - 953
Main Authors Laznicek, M, Laznickova, A, Budsky, F, Prokop, J, Kopicka, K
Format Journal Article
LanguageEnglish
Published 01.01.1994
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Summary:The pharmacokinetics and elimination of EDTMP chelates with different radionuclides ( super(99m)Tc, super(111)In and super(153)Sm) has been investigated in rats. The biodistribution of the complexes under study was similar and two main processes, namely bone uptake and the elimination of glomerular filtration, take part in their rapid blood clearance. A substantially slower blood clearance of super(111)In-EDTMP in comparison with the other complexes suggests partial indium exchange between the chelate and transferrin. All the complexes exhibited high affinity for bone and the radionuclide uptake into the skeleton was in the order super(153)Sm> super(111)In> super(99m)Tc. No specific extra-skeletal uptake was found.
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ISSN:0969-8043