NMR Based Metabolomics Evaluation in Neonatal Calves with Acute Diarrhea and Suspected Sepsis: A New Approach for Biomarker/S
Metabolic consequences of diarrhea-induced sepsis revealed by plasma 1H-Nuclear Magnetic Resonance (NMR) quantitative metabolomics. Diarrhea and sepsis is generally the most common cause of morbidity and mortality in pre-weaned calves. Traditional biomarkers for sepsis are mainly derived from host i...
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Published in | Metabolomics Vol. 4; no. 2; p. 1 |
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Main Authors | , , , , |
Format | Journal Article |
Language | English |
Published |
01.01.2014
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Online Access | Get full text |
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Summary: | Metabolic consequences of diarrhea-induced sepsis revealed by plasma 1H-Nuclear Magnetic Resonance (NMR) quantitative metabolomics. Diarrhea and sepsis is generally the most common cause of morbidity and mortality in pre-weaned calves. Traditional biomarkers for sepsis are mainly derived from host immune/inflammatory response. Various high-throughput omics technologies facilitate comprehensive screening of sepsis-specific biomarkers in human medicine. The aim of this first study was to reveal the new potential biomarkers in diarrhea-induced septic neonatal calves evaluating by 1H-NMR based quantitative metabolomics. Clinical and laboratory data revealed all the ill calves had leukocytosis, metabolic acidosis and failure of colostral passive transfer. This study produced quantitative data sets that presented differences between patients with diarrhea-induced sepsis and healthy subjects in the level of the water and lipid soluble metabolites. This pilot study showed the implementation of plasma 1H-NMR quantitative metabolomics, because it produced a physiologically relevant metabolite data set that distinguished diarrhea-induced sepsis from healthy ones. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 content type line 23 ObjectType-Feature-2 |
ISSN: | 1573-3882 1573-3890 |