Vascular reactivity and ACE activity response to exercise training are modulated by the +9/-9 bradykinin B sub(2) receptor gene functional polymorphism

• Published in: Physiological genomics Vol. 45; no. 12; pp. 487 - 492
• Main Authors: Alves, Cleber Rene, Alves, Guilherme Barreto, Pereira, Alexandre Costa, Trombetta, Ivani Credidio, Dias, Rodrigo Goncalves, Mota, Gloria F A, Fernandes, Tiago, Krieger, Jose Eduardo, Negrao, Carlos Eduardo, Oliveira, Edilamar Menezes
• Format: Journal Article
• Language: English
• Published: 15.06.2013
• ISSN: 1094-8341; 1531-2267
• DOI: 10.1152/physiolgenomics.00065.2012

The bradykinin receptor B sub(2) (BDKRB sub(2)) gene +9/-9 polymorphism has been associated with higher gene transcriptional activity, and characteristics of cardiovascular phenotypes and physical performance. We hypothesized that vasodilation and ACE activity response to exercise training is modulated by BDKRB sub(2) gene. We genotyped 71 healthy volunteers were genotyped for the BDKRB sub(2) gene polymorphism. Heart rate (HR), mean blood pressure (MBP), and forearm blood flow (FBF) were evaluated. Angiotensin-I converting enzyme (ACE) activity was measured by fluorescence. Aerobic training was performed for 16 wk. All variables were reassessed after completion of the training period. In pretraining period, HR, MBP, FBF, and forearm vascular conductance (FVC) were similar among all genotypes. After physical training, the FBF and the FVC response during handgrip exercise such as area under the curve were higher in -9/-9 carriers than the other two groups. However, there were no changes in HR and MBP for all three groups. In addition, in posttraining period the decrease in ACE activity was higher in the -9/-9 group than the other two groups. These results suggest that reflex muscle vasodilation and ACE activity in response to exercise training are modulated by BDKRB sub(2) gene +9/-9 polymorphism in healthy individuals.