Design and synthesis of new tricyclic indoles as potent modulators of the S1P sub(1) receptor
Modulators of S1P sub(1) have proven utility for the treatment of autoimmune disease and efforts to identify new agents with improved safety and pharmacokinetic parameters are ongoing. Several new S1P sub(1) chemotypes were designed and optimized for potency and oral bioavailability. These new agent...
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Published in | Bioorganic & medicinal chemistry letters Vol. 25; no. 3; pp. 659 - 663 |
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Main Authors | , , , , , , , , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
01.02.2015
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Online Access | Get full text |
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Summary: | Modulators of S1P sub(1) have proven utility for the treatment of autoimmune disease and efforts to identify new agents with improved safety and pharmacokinetic parameters are ongoing. Several new S1P sub(1) chemotypes were designed and optimized for potency and oral bioavailability. These new agents are characterized by a 'tricyclic fused indole array' and are highly potent agonists of the S1P sub(1) receptor. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 content type line 23 ObjectType-Feature-2 |
ISSN: | 0960-894X |
DOI: | 10.1016/j.bmcl.2014.11.089 |