A 48 Year Old Woman with a Rare Case of a Midline Destructive Disease Presenting as Having Both Midline and Nonmidline Lesions - A Case Report

• Published in: Molecular therapy Vol. 19; no. 7; p. 1398
• Main Authors: Fernandez, Stephanie, Lapus, Felycette G, Barez, Marie Yvette
• Format: Journal Article
• Language: English
• Published: 01.07.2011
• ISSN: 1525-0016; 1525-0024

Objectives: To describe a rare case of lethal midline granuloma presenting in a rare location. This type of lymphoma which needs a tissue biopsy for diagnosis and immunohistochemical staining for confirmation is a challenge in a developing nation to diagnose, treat and follow up. This paper is presented to be able to show how a rare case of lymphoma was appropriately diagnosed in sans the modern methods of immunohistochemical staining with promising results of chemotherapy. Methods: Case Report. Results: Midline destructive lesions are a heterogeneous group of rare lesions where the classification angiocentric lymphoma, or peripheral Natural Killer/T cell lymphoma, nasal type belongs. It usually presents with destructive mass lesions and extensive destruction in the midfacial areas. We describe a case of an angiocentric lymphoma, or Natural Killer/T cell lymphoma who presented with both a nasal mass and a skin lesion in the medial aspect of her left leg. A tissue biopsy was done to make the diagnosis. She underwent six cycles of chemotherapy and radiotherapy with very promising results. Conclusions: We report this case to document a rare type of lymphoma. Our patient was unique in that she presented with a rare type of lymphoma that is not usually documented in the Philippines and is rare even in international reports. Moreover, she presented also unusually having both a nasal mass and a skin lesion in the medial aspect of her left leg.