Coupling of muscarinic receptors to the mobilization of intracellular Ca super(2+) stores in permeabilized SH-SY5Y human neuroblastoma cells

Intracellular stores of Ca super(2+) were mobilized transiently by carbachol in suspensions of electrically permeabilized SH-SY5Y cells. The data show that functional coupling of muscarinic receptors to Ca super(2+) mobilization can be maintained after permeabilization, reveal major effects of guani...

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Published inBiochemical journal Vol. 272; no. 1; pp. 269 - 272
Main Authors Wojcikiewicz, RJH, Safrany, ST, Challiss, RAJ, Strupish, J, Nahorski, SR
Format Journal Article
LanguageEnglish
Published 01.01.1990
Subjects
acetylcholine
calcium
humans
mechanisms
muscarinic
neuroblastoma
receptors
release
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Summary:Intracellular stores of Ca super(2+) were mobilized transiently by carbachol in suspensions of electrically permeabilized SH-SY5Y cells. The data show that functional coupling of muscarinic receptors to Ca super(2+) mobilization can be maintained after permeabilization, reveal major effects of guanine nucleotides on agonist-induced Ca super(2+) mobilization and provide a basis for explanation of discrepancies between agonist potency on inositol 1,4,5-trisphosphate concentration and Ca super(2+) mobilization in intact cells. (DBO)
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
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ISSN:0264-6021