Oxygen radicals, cytokines, adhesion molecules, and lung injury

• Published in: Environmental Health Perspectives [ENVIRON. HEALTH PERSPECT.]. Vol. 102, no. 10 Suppl. 1994 Vol. 102; p. no. 10 Sul.
• Main Author: Ward, P A
• Format: Conference Proceeding
• Language: English
• Published: 01.01.1994
• ISSN: 0091-6765

Inflammatory injury in the lung or dermis occurring after systemic activation of complement or after local deposition of immune complexes is related to local activation of tissue macrophages and/or recruitment of blood neutrophils. While requirements for cytokines (IL-1, TNF alpha , MCP-1) vary with the model of injury, requirements for adhesion molecules ( beta 2 integrins, selectins, ICAM-1) differ. In most cases the immediate events related to tissue injury can be linked to toxic products from oxygen and L-arginine. Whether there is a single toxic product or a variety of toxic products remains to be determined. These data emphasize similarities and differences in the mechanisms of inflammatory injury, as a function of the inciting inflammatory agent and the organ system involved.