Study of humoral immune response in mammals immunized with Plasmodium falciparum antigenic preparations

Six Plasmodium falciparum protein fractions, isolated under reducing conditions, were used to immunize mice, rabbits and the squirrel monkey Saimiri sciureus . Five or seven subcutaneous injections of each antigenic preparation, in conjunction with Freund's complete or incomplete adjuvants, wer...

Full description

Saved in:
Bibliographic Details
Published inMemorias do Instituto Oswaldo Cruz [MEM. INST. OSWALDO CRUZ.]. Vol. 87, no. Suppl. III. 1992 Vol. 87; p. no. Sul. III
Main Authors Cruz Cubas, AB, Cunha, F, Nitcheu, I K, Rolland, L, Ciceron, L, Carvalho, AB, Furtado, A F, Monjour, L
Format Conference Proceeding
LanguageEnglish
Published 01.01.1992
Subjects
Plasmodium falciparum
Online AccessGet full text

Cover

More Information
Summary:Six Plasmodium falciparum protein fractions, isolated under reducing conditions, were used to immunize mice, rabbits and the squirrel monkey Saimiri sciureus . Five or seven subcutaneous injections of each antigenic preparation, in conjunction with Freund's complete or incomplete adjuvants, were administered. This led to the development of specific antibodies detected by IFAT, ELISA or immunobloting which inhibited merozoite reinvasion in in vitro P. falciparum cultures. This activity seems to be associated with rhoptry proteins contained in fractions Pf F2 and Pf F4.
Bibliography:SourceType-Books-1
ObjectType-Conference-2
SourceType-Conference Papers & Proceedings-2
ObjectType-Book-1
content type line 25
ISSN:0074-0276