Locomotor responses of human CD45 lymphocyte subsets: Preferential locomotion of CD45RO super(+) lymphocytes in response to attractants and mitogens

• Published in: Immunology Vol. 78; no. 1; pp. 92 - 98
• Main Authors: Newman, I, Wilkinson, P C
• Format: Journal Article
• Language: English
• Published: 01.01.1993
• ISSN: 0019-2805

The CD45RO super(+) population of lymphocytes from human blood contains a higher proportion of locomotor cells than the CD45RA super(+) population. Direct from blood there were few locomotor lymphocytes (< 15%), but, among these, a higher proportion of CD45RO super(+) than of CD45RA super(+) cells responded to the chemotactic stimuli, foetal calf serum (FCS) and interleukin-2 (IL-2) in polarization assays. Likewise, after overnight culture, a higher proportion of CD45RO super(+) cells responded to IL-8. The findings suggest that, not only selective adhesion to vascular endothelium as reported earlier, but also selective locomotion recruits CD45RO super(+) lymphocytes into sites of inflammation. (DBO)