GW24-e2371The association between KCNJ5 gene polymorphism and primary aldosteronism

• Published in: Heart (British Cardiac Society) Vol. 99; no. Suppl 3; p. A62
• Main Authors: Chao, Shi, Hongjian, Li, Feiya, Zu, Delian, Zhang, Guijuan, Chang, Nanfang, Li
• Format: Journal Article
• Language: English
• Published: 01.08.2013
• ISSN: 1468-201X
• DOI: 10.1136/heartjnl-2013-304613.172

ObjectivesTo investigate the association of rs1221497 in KCNJ5 gene and primary aldosteronism (PA). KCNJ5 is a gene encoding a G-protein-coupled inwardly rectifying potassium.MethodsA total of 218 PA patients and 853 essential hypertension (EH) patients was enrolled in this study, taqMan assay was used to detect the rs1221497 polymorphism of KCNJ5 gene.ResultsThe genotypes of rs1221497 were in H-W equilibrium in both PA group and EH group, the genotype frequencies of GG, GC, CC were 208, 39, 1 in PA group and 631, 177, 8 in EH group; the allele frequencies in the two group were 455, 41 and 1439, 193 respectively. The distribution of GG genotype and G allele differ significantly between PA group and EH group. Logistic regression showed that GG genotype was also associated with PA after adjusting age.ConclusionsGG genotype and G allele may contribute to the occurrence of PA.