SYNTHESIS OF NOVEL SERIES OF 2-AMINO-1, 2-DIHYDROISOQUINOLINE-3(4H)-ONE DERIVATIVES USED AS ANTIMICROBIAL AND ANTIOXIDANT AGENTS

A facile synthesis of novel 2-amino-1,2- dihydroisoquinoline-3(4H)-one and their amide derivatives (6a-o) through sydnone intermediate (3) was derived from tetrahydroisoquinoline-3-carboxylic acid (1) and various substituted phenyl acrylic acid derivatives (5a-o) in short reaction time with good yie...

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Published inInternational journal of pharmaceutical sciences and research Vol. 5; no. 11; p. 4953
Main Authors Mani, Umamaheswari, Rathinasamy, Suresh, Kaliyamoorthy, Vadivel, Rajagopal, Sridharan, Mohan, Palathurai Subramaniam
Format Journal Article
LanguageEnglish
Published 01.01.2014
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Summary:A facile synthesis of novel 2-amino-1,2- dihydroisoquinoline-3(4H)-one and their amide derivatives (6a-o) through sydnone intermediate (3) was derived from tetrahydroisoquinoline-3-carboxylic acid (1) and various substituted phenyl acrylic acid derivatives (5a-o) in short reaction time with good yield. The structure of all novel synthesized compounds was established based on Mass, super( 1)H NMR, super( 13)C NMR, IR spectral data and Single crystal X-ray study (6e). All the synthesized compounds were evaluated for their antimicrobial and antioxidant activities.
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ISSN:0975-8232