Nicotinamide ethers: Novel inhibitors of calcium-independent phosphodiesterase and ( super(3)H)rolipram binding

The synthesis and biological properties of a series of nicotinamide ethers are described. These compounds, structurally novel calcium-independent phosphodiesterase inhibitors, also inhibit the binding of ( super(3)H)rolipram to rat brain membranes and reverse reserpine-induced hypothermia in the mou...

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Published inJournal of medicinal chemistry Vol. 34; no. 1; pp. 86 - 89
Main Authors Vinick, F J, Saccomano, NA, Koe, B K, Nielsen, JA, Williams, I H, Thadeio, P F, Jung, S, Meltz, M, Johnson, J Jr
Format Journal Article
LanguageEnglish
Published 01.01.1991
Subjects
analogs
inhibition
nicotiamide
phosphodiesterase
synthesis
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Summary:The synthesis and biological properties of a series of nicotinamide ethers are described. These compounds, structurally novel calcium-independent phosphodiesterase inhibitors, also inhibit the binding of ( super(3)H)rolipram to rat brain membranes and reverse reserpine-induced hypothermia in the mouse. Several compounds exhibited potent in vivo activity comparable to the standard agent, rolipram.
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SourceType-Scholarly Journals-1
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ISSN:0022-2623