The nature of Cl super(-) secretion, induced by carbaryl, across the isolated skin of Rana esculenta

The pesticide carbaryl induces Cl super(-) secretion through the isolated frog (Rana esculenta)) skin. This effect is due to the activation of both processes responsible for this phenomenon: (a) Na super(+)/k super(+)/2Cl super(-) cotransport on the serosal membrane; (b) Cl super(-) selective channe...

Full description

Saved in:
Bibliographic Details
Published inComparative biochemistry and physiology. C, Comparative pharmacology and toxicology Vol. 103C; no. 2; pp. 387 - 389
Main Authors Lippe, C, Bellantuono, V, Valenti, G, Ardizzone, C
Format Journal Article
LanguageEnglish
Published 01.01.1992
Subjects
chloride
chlorides
effects on
Freshwater
insecticides
integumentary system
ion transport
pollution effects
Rana esculenta
secretion
skin
Online AccessGet full text

Cover

More Information
Summary:The pesticide carbaryl induces Cl super(-) secretion through the isolated frog (Rana esculenta)) skin. This effect is due to the activation of both processes responsible for this phenomenon: (a) Na super(+)/k super(+)/2Cl super(-) cotransport on the serosal membrane; (b) Cl super(-) selective channels on the external membrane. Cl super(-) outflux is inhibited by bumetanide (10 super(-5) M) on the serosal side and by diphenylamine-2-carboxylic acid (DPC) (10 super(-3) M) on the external side. The DPC action is not mimicked by Naproxen, a specific inhibitor of cyclooxygenase. A comparison with isoprenaline, demonstrates that the carbaryl action is, paradoxically, more selective than that of isoprenaline. This selectivity of carbaryl action on Cl super(-) permeability is confirmed by the fact that, unlike isoprenaline, carbaryl does not affect the permeability of Na super(+) and thiourea.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
content type line 23
ObjectType-Feature-2
ISSN:0742-8413