The nature of Cl super(-) secretion, induced by carbaryl, across the isolated skin of Rana esculenta
The pesticide carbaryl induces Cl super(-) secretion through the isolated frog (Rana esculenta)) skin. This effect is due to the activation of both processes responsible for this phenomenon: (a) Na super(+)/k super(+)/2Cl super(-) cotransport on the serosal membrane; (b) Cl super(-) selective channe...
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Published in | Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology Vol. 103C; no. 2; pp. 387 - 389 |
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Main Authors | , , , |
Format | Journal Article |
Language | English |
Published |
01.01.1992
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Subjects | |
Online Access | Get full text |
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Summary: | The pesticide carbaryl induces Cl super(-) secretion through the isolated frog (Rana esculenta)) skin. This effect is due to the activation of both processes responsible for this phenomenon: (a) Na super(+)/k super(+)/2Cl super(-) cotransport on the serosal membrane; (b) Cl super(-) selective channels on the external membrane. Cl super(-) outflux is inhibited by bumetanide (10 super(-5) M) on the serosal side and by diphenylamine-2-carboxylic acid (DPC) (10 super(-3) M) on the external side. The DPC action is not mimicked by Naproxen, a specific inhibitor of cyclooxygenase. A comparison with isoprenaline, demonstrates that the carbaryl action is, paradoxically, more selective than that of isoprenaline. This selectivity of carbaryl action on Cl super(-) permeability is confirmed by the fact that, unlike isoprenaline, carbaryl does not affect the permeability of Na super(+) and thiourea. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 content type line 23 ObjectType-Feature-2 |
ISSN: | 0742-8413 |