The ACTH.MSH(4-9) analogue ORG 2766 stimulates microtubule formation in axons of central neurons of the snail Lymnaea stagnalis

Central nervous systems of the pond snail Lymnaea stagnalis were incubated in vitro in different concentrations of ORG 2766 (10 super(-9) - 2.5 x 10 super(-4) M) for 10 and 20 h. Quantitative ultrastructural study of cross sections of the cerebral commissure showed that the number of microtubules in...

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Published inPeptides (New York, N.Y. : 1980) Vol. 13; no. 4; pp. 769 - 774
Main Authors Mueller, L J, Moorer-van Delft, CM, Boer, H H
Format Journal Article
LanguageEnglish
Published 01.01.1992
Subjects
adrenocorticotropic hormone
analogs
axons
effects on
formation
Lymnaea stagnalis
melanocyte-stimulating hormone
microtubules
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Summary:Central nervous systems of the pond snail Lymnaea stagnalis were incubated in vitro in different concentrations of ORG 2766 (10 super(-9) - 2.5 x 10 super(-4) M) for 10 and 20 h. Quantitative ultrastructural study of cross sections of the cerebral commissure showed that the number of microtubules in large axons had increased after 10 h of incubation by approximately 50% (Experiment 1) and 30% (Experiment 2), respectively. No further increase was observed after 20 h of incubation. (The higher concentrations were studied.) Maximal stimulation was already found at a concentration of 10 super(-8) M. At a concentration of 10 super(-9) M control levels were observed. It is concluded that ORG 2766 stimulates microtubule formation already at very low concentrations.
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ISSN:0196-9781