Prone-position acquisition of myocardial super(123)I-metaiodobenzylguanidine (MIBG) SPECT reveals regional uptake similar to that found using super(11)C-hydroxyephedrine PET/CT

• Published in: Annals of nuclear medicine Vol. 28; no. 8; pp. 761 - 769
• Main Authors: Yoshinaga, Keiichiro, Tomiyama, Yuuki, Manabe, Osamu, Kasai, Katsuhiko, Katoh, Chietsugu, Magota, Kenichi, Suzuki, Eriko, Nishijima, Ken-ichi, Kuge, Yuji, Ito, Yoichi M, Tamaki, Nagara
• Format: Journal Article
• Language: English
• Published: 01.10.2014
• ISSN: 0914-7187; 1864-6433
• DOI: 10.1007/s12149-014-0868-z

Objectives: super(123)I-metaiodobenzylguanidine (MIBG) has been used to estimate cardiac sympathetic nervous innervation. Heterogeneous MIBG distribution is mainly associated with high physiological MIBG uptakes in the liver. We postulate that prone position acquisition might be especially effective for MIBG, providing for separation from high liver uptake similar to that provided by perfusion single-photon emission computed tomography (SPECT). We investigated whether prone-position acquisition improved MIBG image quality by comparing our results to those acquired using supine MIBG and high-quality super(11)C-hydroxyephedrine (HED) positron emission tomography/computed tomography PET/CT. Methods: Ten male volunteers (body mass index (BMI) 22.7 plus or minus 3.4) underwent prone and supine MIBG and HED PET. Relative regional tracer uptake was estimated in early MIBG and HED. Acquired images were divided into 17 segments and were grouped into 4 regions: anterior, inferior, septum, and lateral. For each patient, the inferior/anterior ratio was calculated. Results: The quality of images acquired using prone MIBG was better than that using supine MIBG (p < 0.05). Inferior and septum relative MIBG uptake was reduced in comparison with anterior or lateral MIBG uptake in the supine position (inferior vs. anterior: 69.0 plus or minus 5.6 vs. 82.3 plus or minus 4.6 %, p < 0.01; septum vs. lateral: 66.2 plus or minus 5.1 vs. 81.9 plus or minus 5.4 %, p < 0.01). Prone MIBG showed a significantly higher inferior/anterior uptake ratio in comparison with supine MIBG (n = 24, seg: 92.2 plus or minus 7.2 vs. 83.6 plus or minus 5.7 %, p < 0.05). However, intergroup differences in uptake ratio were demonstrated among prone and supine MIBG and HED. HED PET/CT still showed a higher uptake ratio in comparison with prone MIBG SPECT (103.9 plus or minus 8.0 vs. 92.2 plus or minus 7.2 %, p < 0.05). Conclusion: Even in normal male subjects, standard supine MIBG imaging showed reduced inferior and septum uptake. Uptake with prone MIBG imaging showed a significant improvement over that with supine imaging and was closer to uptake for HED PET/CT. This improvement may be the result of preventing intense uptake by the liver. Prone data acquisition may be a viable alternative in evaluating regional abnormalities using MIBG SPECT in men.