Amylin or CGRP (8-37) fragments reverse amylin-induced inhibition of super(14)C-glycogen accumulation

The peptides amylin and calcitonin-gene related peptide (CGRP) have been shown to have similar effects on glycogen metabolism in vivo and in vitro. Peptide fragments based on the amino acid sequence of amylin or CGRP were evaluated for their ability to inhibit the action of the peptides in vitro. Th...

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Bibliographic Details
Published inBiochemical and biophysical research communications Vol. 181; no. 1; pp. 116 - 120
Main Authors Deems, RO, Cardinaux, F, Deacon, R W, Young, DA
Format Journal Article
LanguageEnglish
Published 01.01.1991
Subjects
calcitonin-gene related peptide
glycogen
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Summary:The peptides amylin and calcitonin-gene related peptide (CGRP) have been shown to have similar effects on glycogen metabolism in vivo and in vitro. Peptide fragments based on the amino acid sequence of amylin or CGRP were evaluated for their ability to inhibit the action of the peptides in vitro. The results demonstrate that amylin (8-37) completely antagonizes the effects of amylin with limited ability to block CGRP.
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ISSN:0006-291X