Inhibition of DNA synthesis in living cells by microinjection of G sub(i2) antibodies

We have attempted to determine which subtypes of G proteins are directly involved in serum-stimulated DNA synthesis through microinjection of inhibitory antibodies into living cells. Results of these experiments indicate that G sub(i2) plays a direct role in serum-stimulated DNA synthesis in living...

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Published inThe Journal of biological chemistry Vol. 267; no. 2; pp. 691 - 694
Main Authors LaMorte, V J, Goldsmith, P K, Spiegel, A M, Meinkoth, J L, Feramisco, J R
Format Journal Article
LanguageEnglish
Published 01.01.1992
Subjects
DNA biosynthesis
fibroblasts
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Summary:We have attempted to determine which subtypes of G proteins are directly involved in serum-stimulated DNA synthesis through microinjection of inhibitory antibodies into living cells. Results of these experiments indicate that G sub(i2) plays a direct role in serum-stimulated DNA synthesis in living cells and suggest that G proteins may function in a variety of mitogenic signaling pathways initiated by serum growth factors.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
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ISSN:0021-9258