Regional localization of the human G protein alpha sub(i2) (GNAI2) gene: Assignment to 3p21 and a related sequence (GNAI2L) to 12p12-p13

G sub(i alpha ) proteins, members of the G protein signal transduction family, include a small number of polypeptides: G sub(i alpha 1) (GNAI1), G sub(i alpha 2) (GNAI2), and G sub(i alpha 3) (GNAI3). A cDNA for the human GNAI2 gene has been isolated from a human T-cell library and is mapped by chro...

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Published inGenomics (San Diego, Calif.) Vol. 12; no. 1; pp. 125 - 129
Main Authors Magovcevic, I, Ang, Siew-Lan, Seidman, J G, Tolman, C J, Neer, E J, Morton, C C
Format Journal Article
LanguageEnglish
Published 01.01.1992
Subjects
chromosome 12
chromosome 3
genes
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Summary:G sub(i alpha ) proteins, members of the G protein signal transduction family, include a small number of polypeptides: G sub(i alpha 1) (GNAI1), G sub(i alpha 2) (GNAI2), and G sub(i alpha 3) (GNAI3). A cDNA for the human GNAI2 gene has been isolated from a human T-cell library and is mapped by chromosomal in situ hybridization to the short arm of chromosome 3 at 3p21. A related sequence, GNAI2L, is mapped by in situ hybridization to the short arm of chromosome 12 at p12-p13. The mapping results are further supported by amplification of GNAI2-specific sequences in a monochromosomal human/rodent somatic cell hybrid containing only human chromosome 3. Of note, these assignments are to chromosome regions in which other G proteins reside.
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ISSN:0888-7543