Retinoic acid modulates both invasion and plasma membrane ruffling of MCF-7 human mammary carcinoma cells in vitro

The invasiveness of MCF-7 human mammary carcinoma cells was tested in vitro via confronting cultures with embryonic chick heart fragments. Invasive (e.g. MCF-7/6) and non-invasive (e.g. MCF-7/AZ) variants were detected. Automated image analysis of time-lapse video-microscopy recordings showed that t...

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Bibliographic Details
Published inBritish journal of cancer Vol. 6; no. 63; pp. 867 - 872
Main Authors Bracke, ME, Van Larebeke, NA, Vyncke, B M, Mareel, M M
Format Journal Article
LanguageEnglish
Published 01.01.1991
Subjects
breast
carcinoma
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Summary:The invasiveness of MCF-7 human mammary carcinoma cells was tested in vitro via confronting cultures with embryonic chick heart fragments. Invasive (e.g. MCF-7/6) and non-invasive (e.g. MCF-7/AZ) variants were detected. Automated image analysis of time-lapse video-microscopy recordings showed that the plasma membrane ruffling activity of the invasive MCF-7/6 variant was higher than the ruffling activity of the non-invasive MCF-7/AZ variant. Our data show that retinoic acid can modulate invasiveness in opposite directions.
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ISSN:0007-0920