Impact of adrenalectomy on 5-HT sub(6) and 5-HT sub(7) receptor gene expression in the rat hippocampus

Both glucocorticoid excess and decreased serotonergic (5-HT) transmission may cause depression. The recently cloned 5-HT6 and 5-HT7 receptors have high affinity for antidepressants. Here, we show that pharmacological adrenalectomy increases 5-HT6 and 5-HT7 receptor mRNA expression in specific hippoc...

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Published inBrain research. Molecular brain research. Vol. 45; no. 1; pp. 182 - 186
Main Authors Yau, Joyce LW, Noble, J, Widdowson, J, Seckl, J R
Format Journal Article
LanguageEnglish
Published 01.04.1997
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Summary:Both glucocorticoid excess and decreased serotonergic (5-HT) transmission may cause depression. The recently cloned 5-HT6 and 5-HT7 receptors have high affinity for antidepressants. Here, we show that pharmacological adrenalectomy increases 5-HT6 and 5-HT7 receptor mRNA expression in specific hippocampal subfields, effects partly reversed by corticosterone replacement. Increased 5-HT6 and 5-HT7 receptor expression may provide a basis, in part, for the therapeutic actions of adrenal steroid synthesis inhibitors in resistant depression.
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SourceType-Scholarly Journals-1
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ISSN:0169-328X