Gramicidin A induced fusion of large unilamellar dioleoylphosphatidyl choline vesicles and its relation to the induction of type II nonbilayer structures

The fusogenic properties of gramicidin were investigated by using large unilamellar dioleoylphosphatidyl-choline vesicles. It is shown that gramicidin induces aggregation and fusion of these vesicles at peptide to lipid molar ratios exceeding 1/100. It is suggested that gramicidin-induced fusion and...

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Published inBiochemistry (Easton) Vol. 29; no. 36; pp. 8297 - 8307
Main Authors Tournois, H, Fabrie, CHJP, Burger, KNJ, Mandersloot, J, Hilgers, P, van Dalen, H, de Gier, J, de Kruijff, B
Format Journal Article
LanguageEnglish
Published 01.01.1990
Subjects
dioleoylphosphatidylcholine
gramicidin A
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Summary:The fusogenic properties of gramicidin were investigated by using large unilamellar dioleoylphosphatidyl-choline vesicles. It is shown that gramicidin induces aggregation and fusion of these vesicles at peptide to lipid molar ratios exceeding 1/100. It is suggested that gramicidin-induced fusion and H sub(II) phase formation share common intermediates.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
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ISSN:0006-2960