M6: Antimicrobial Activity of Secondary Metabolites from Marine Bacteria Isolated from Malaysian East Coast Area

Marine bacteria have been the study of importance in recent years because of production of novel metabolites, which serve as model systems in discovery of new drugs. The emergence of antibiotic resistant pathogens (for example penicillin-resistant Staphylococcus aureus) is a major concern in public...

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Published inAsia-Pacific journal of molecular biology and biotechnology Vol. 20; no. 4; pp. 28 - 29
Main Authors Mazalan, Norfaezah, Zain, Mazatulikhma Mat, Hamzah, Ahmad Sazali, Mahmud, Abdul Hadi, Hasaza, Aina Nabilah, Ibrahim, Mohamad Shamil Anwar, Omar, Nurfarahana Syuhada, Azhar, Wan Azrul Wan, Hanaffi, Wan Nur Hidayah Wan
Format Journal Article
LanguageEnglish
Published 01.12.2012
Subjects
Bacillus subtilis
Candida albicans
Citrobacter diversus
Escherichia coli
Klebsiella pneumoniae
Pseudomonas aeruginosa
Staphylococcus aureus
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Summary:Marine bacteria have been the study of importance in recent years because of production of novel metabolites, which serve as model systems in discovery of new drugs. The emergence of antibiotic resistant pathogens (for example penicillin-resistant Staphylococcus aureus) is a major concern in public health nowadays. This study explored marine bacteria with medical potential, in which the marine bacteria were sampled from sea water collected from different areas of Pulau Kapas Beach and Pantai Batu Burok, Terengganu. The growth curves of these different strains and pure cultures of marine bacteria were studied and the antimicrobial activities were determined by observing bacterial and fungal growth inhibition. Organic extracts (hexane, ethyl acetate, and butanol) of marine bacterial fermentation were screened for antimicrobial activities using disk diffusion method. The identification focused on isolate designated as A4 and expected to be Citrobacter diversus. The results revealed that the isolate A4 entered the stationary phase at 10 hours of growth. The ethyl acetate extracts displayed antibacterial activity against Bacillus subtilis, Staphylococcus aureus, Klebsiella pneumoniae, and Pseudomonas aeruginosa, but possessed no effect on bacterium Escherichia coli, and yeasts Candida albicans. These results indicate that marine microorganisms could be a promising source for antimicrobial bioactive agents for gram positive bacteria.
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ISSN:0128-7451