The induction of tyrosine aminotransferase activity and its use as an indirect assay for endotoxin in mice infected with Plasmodium vinchei petteri
It has been suggested that the malaria parasite contains an endotoxin-like substance which, by activating the reticuloendothelial system, causes much of the pathology of malaria when it is released into the host bloodstream during schizogony. In this study, an in vivo assay was developed, based on t...
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| Published in | International journal for parasitology Vol. 12; no. 4; pp. 279 - 284 |
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| Main Authors | , , , |
| Format | Journal Article |
| Language | English |
| Published |
01.01.1982
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| Subjects | |
| Online Access | Get full text |
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| Summary: | It has been suggested that the malaria parasite contains an endotoxin-like substance which, by activating the reticuloendothelial system, causes much of the pathology of malaria when it is released into the host bloodstream during schizogony. In this study, an in vivo assay was developed, based on the determination of hepatic tyrosine aminotransferase activity in infected mice, to measure substances which act like endotoxin. Tryosine aminotransferase is important in gluconeogenesis and is induced by endotoxin. Mice infected with Plasmodium vinckei petteri become sensitised to bacterial endotoxin as small amounts of endotoxin, without effect in uninfected mice, elevate tyrosine aminotransferase activity. |
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| Bibliography: | ObjectType-Article-2 SourceType-Scholarly Journals-1 content type line 23 ObjectType-Feature-1 |
| ISSN: | 0020-7519 |