Response to Single Dose of Tetanus Vaccine in Subjects With Naturally Acquired Tetanus Antitoxin

Tests among 410 Indians not artificially immunised against tetanus showed that 80% had measurable antitoxin. Single doses of a potent tetanus toxoid were given to such individuals with naturally acquired antitoxin. The 100 Lf dose produced on average a ten-fold rise in antibody level, and the 250 Lf...

Full description

Saved in:
Bibliographic Details
Published inThe Lancet (North American edition) Vol. 2; no. 8240; pp. 219 - 224
Main Authors Dastur, F D, Awatramani, V P, Dixit, S K, D'Sa, JA, Cooverji, N D, Anand, M P
Format Journal Article
LanguageEnglish
Published 01.01.1981
Subjects
Clostridium tetani
India
Online AccessGet full text

Cover

More Information
Summary:Tests among 410 Indians not artificially immunised against tetanus showed that 80% had measurable antitoxin. Single doses of a potent tetanus toxoid were given to such individuals with naturally acquired antitoxin. The 100 Lf dose produced on average a ten-fold rise in antibody level, and the 250 Lf dose a twenty-fold rise. Single-dose vaccination may be better than the conventional three-dose scheme for a population that is unlikely to comply with a three-dose regiment and in whom naturally acquired antitoxin is associated with partial tolerance to tetanus toxoid. Naturally acquired antitoxin in Indians is probably the result of chronic clostridial contamination of the small bowel. This contamination can induce immune tolerance in the gut and systemically and may be the reason for the poor responses to vaccination in all except infants.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
content type line 23
ObjectType-Feature-1
ISSN:0099-5355