Guanine Nucleotides do not Inhibit Tritiated Dopamine Agonist Binding to Bovine Striatal Membranes

• Published in: Neurochemical research Vol. 7; no. 7; pp. 831 - 837
• Main Authors: Near, JA, Mahler, H R
• Format: Journal Article
• Language: English
• Published: 01.01.2002
• Subjects: cattle; dopamine; GTP; inhibition; spiperone; striate cortex

The addition of GTP (50 mu M), MnCl sub(2) (1 mM) or EDTA (2 mM) had no effect on the affinity or capacity of bovine striatal plasma membranes for ( super(3)H)spiperone. However, GTP caused a decrease in the potency of dopamine as an inhibitor of ( super(3)H)spiperone binding under all conditions te...