Early abnormal development of calmodulin gene expression and calmodulin-resistant Ca super(2+)-ATPase activity in avian dystrophic muscle

The authors have reported previously that the pectoralis muscle from three-month-old dystrophic chickens with signs of myopathy exhibits increased calmodulin content, elevated calmodulin-specific mRNA, and reduced sarcoplasmic reticulum (SR) Ca super(2+)-ATPase activity in response to calmodulin exp...

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Published inBiochemical and biophysical research communications Vol. 151; no. 3; pp. 1434 - 1440
Main Authors Thacore, H R, Kibler, P K, Hudecki, MS, Galindo, J Jr, Davis, F B, Davis, P J, Pollina, C M, Blas, S D, Schoenl, M
Format Journal Article
LanguageEnglish
Published 01.01.1988
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Summary:The authors have reported previously that the pectoralis muscle from three-month-old dystrophic chickens with signs of myopathy exhibits increased calmodulin content, elevated calmodulin-specific mRNA, and reduced sarcoplasmic reticulum (SR) Ca super(2+)-ATPase activity in response to calmodulin exposure in vitro. To determine the early time sequence for development of these abnormalities, they have studied muscle from embryos and post-hatched chickens at various ages. The findings suggest that the genetic lesion expressed in the avian dystrophic animal model involves the loss of normal control of intracellular calcium metabolism early in the maturation of the affected musculature and prior to appearance of disease signs.
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ISSN:0006-291X