Anticandidal properties of N super(3)-(4-methoxyfumaroyl)-L-2,3-diaminopropanoic acid oligopeptides

Tri-, tetra-, and pentapeptides containing N super(3)-(4-methoxyfumaroyl)-L-2,3-diaminopropanoic acid (FMDP), an inactivator of glucosamine 6-phosphate synthase of fungal origin (a key enzyme in the biosynthesis of macromolecular components of the fungal cell wall) have been synthesized and investig...

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Bibliographic Details
Published inJournal of medicinal chemistry Vol. 33; no. 1; pp. 132 - 135
Main Authors Andruszkiewicz, R, Milewski, S, Zieniawa, T, Borowski, E
Format Journal Article
LanguageEnglish
Published 01.01.1990
Subjects
Candida
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Summary:Tri-, tetra-, and pentapeptides containing N super(3)-(4-methoxyfumaroyl)-L-2,3-diaminopropanoic acid (FMDP), an inactivator of glucosamine 6-phosphate synthase of fungal origin (a key enzyme in the biosynthesis of macromolecular components of the fungal cell wall) have been synthesized and investigated as anticandidal agents. Structure-activity relationships of a series of peptides revealed that tripeptides were generally more active than the other peptides examined. In this study, the lysyl peptide, Lys-Nva-FMDP has been found to be the most active compound in the series.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
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ISSN:0022-2623