Interleukin-1Beta is associated with depressive episode in major depression but not in bipolar disorder

• Published in: Journal of psychiatric research Vol. 47; no. 12; pp. 2011 - 2014
• Main Authors: Mota, Rosana, Gazal, Marta, Acosta, Bruna A, de Leon, Pamela B, Jansen, Karen, Pinheiro, Ricardo T, Souza, Luciano D, Silva, Ricardo A, Oses, Jean P, Quevedo, Luciana, Lara, Diogo R, Ghisleni, Gabriele, Kaster, Manuella P
• Format: Journal Article
• Language: English
• Published: 01.12.2013
• Subjects: Bipolar affective disorder; Depression; Gender differences; Mania; Moods; Psychotropic drugs
• ISSN: 0022-3956
• DOI: 10.1016/j.jpsychires.2013.08.020

Our work was sought to investigate possible changes in peripheral levels of interleukin-1Beta (IL-1Beta) according to the diagnosis of major depression (MD) and bipolar disorder (BD) and in different mood episodes. This is a cross-sectional nested in a population-based study comparing 240 young adults (80 controls, 80 MD and 80 BD), balanced for age and gender. Serum levels of IL-1Beta were significantly higher in MD when compared to control or BD subjects. In addition, when divided by current mood episode, MD subjects in current depression presented higher IL-1Beta levels than controls. No differences in IL-1Beta levels were found between different episodes of BD (euthymic, depressed, mania or mixed). Moreover, the use of psychiatric medication was very low in our sample and not associated with changes in IL-1Beta levels. In conclusion, increased peripheral IL-1Beta might be a useful marker associated with a depressive episode in the context of MD. [Copyright Elsevier Ltd.]