Delayed cerebrospinal fluid sterilization in infants with Haemophilus influenzae type b meningitis

Cerebrospinal fluid (CSF) sterilization after > 24 h of intravenous antibiotic therapy (delayed CSF sterilization) was noted in two infants treated with ceftizoxime and ceftazidime for bacterial meningitis. A case-control study was conducted of children between 6 w and 6 y of age treated between...

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Published inThe Journal of infectious diseases Vol. 160; no. 4; pp. 711 - 715
Main Authors Hatch, D L, Overturf, G D
Format Journal Article
LanguageEnglish
Published 01.01.1989
Subjects
Haemophilus influenzae
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Summary:Cerebrospinal fluid (CSF) sterilization after > 24 h of intravenous antibiotic therapy (delayed CSF sterilization) was noted in two infants treated with ceftizoxime and ceftazidime for bacterial meningitis. A case-control study was conducted of children between 6 w and 6 y of age treated between 1975 and 1985 at one institution for bacterial meningitis to determine risk factors for delayed CSF sterilization. Haemophilus influenzae type b was isolated from all children (n = 5) with delayed CSF sterilization, compared with only 78% of all children in the study (n = 83). In children with H. influenzae type b disease, children < 6 mo of age were at higher risk than older children for delayed CSF sterilization (odds ratio = 7.5). Factors not associated with delayed CSF sterilization included time of follow-up lumbar puncture, CSF total or differential white blood cell count, and CSF protein and glucose concentrations.
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ISSN:0022-1899